Kaneka's advanced technology platform consists of biotechnology, synthetic technology and various combinations thereof. Even though such a technology combination may not seem unusual these days, Kaneka pioneered this hybrid technology approach and remains at the leading edge of the latest advances in this field. The feature of Kaneka's creative solutions in this field is our sophisticated selection and combination of the stereoselective ability of enzymes and organic synthesis. Kaneka's expertise in process engineering and scale-up technology supports an efficient large-scale commercial production. The "Enzymatic Reduction System" can be applied to a wide variety of chiral alcohols and is one of the most powerful items in Kaneka's technology toolbox. Kaneka's recombinant enzyme library has enabled Kaneka to provide intelligent solutions to customers' process challenges and manufacture 100's kg of chiral alcohols in 1-2 months at hitherto unattainable quality. Such solutions enable our customers to accelerate their drug development timelines. Enzymatic Reaction Microbial Reaction Fermentation Gene Technology Protein Engineering Immobilization of Enzyme/ Microorganisms Asymmetric Synthesis Optical Resolution Hydrogenation Organometallic Reaction Sulfur Chemistry Friedel-Crafts Reaction High Temperature Reaction (up to 200°C) Low Temperature Reaction (down to -100°C) Cyanation Phosgenation General Organic Synthesis Enzymatic Reduction System Bioreactor of Immobilized Enzymes for D-Amino Acids Production Microbial Reactions Asymmetric Inductions Combination: Asymmetric Synthesis Following Microbial/Enzymatic Reactions

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