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| A complicated key-intermediate for ß-lactam antibiotics can be synthesized from a simple chiral building block, ß-hydroxyester which is produced with high optical purity using our microbial/enzymatic reactions. A stereoselective [2+2] cycloadditon of an enol ether gives rise to the formation of a ß-lactam ring with complete stereo-control of two chiral centers at extremely low temperature. The compound is utilized for synthesis of various types of penems and carbapenems. |
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