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Microbial reactions are superior to conventional synthetic reactions in that they feature perfect optical purity and high productivity of chiral alcohols on a commercial scale.
Racemic diol can be transformed to the pure S-isomer using Kaneka's microbial stereo-inversion system. The R-isomer is, passing through ketone, converted to the corresponding S-isomer, while the S-isomer remains, due to the lack of S-specific oxidation. The microbial stereo-inversion system has been applied to the manufacture of a variety of chiral diols. |
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| Chiral ß-Hydroxycarboxylic acids are produced by utilizing the ß-oxidation pathway of lipid metabolism. The selected microbial strains lacking the dehydrogenase shown below efficiently accumulate either the R or the S isomer of the alcohol with excellent yield and optical purity. Kaneka produces a variety of advanced intermediates from chiral ß-Hydroxycrboxylic acids as chiral building blocks using our synthetic technology expertise. |
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