Kaneka's seamless manufacturing facilities have the ability to respond to a wide range of volume and technology production needs. Kaneka's manufacturing facilities are operated in an organic harmony corresponding to the effective combination of biotechnology and synthetic technology. High productivity using a three-shift-basis operation (24 hr staffing) at all manufacturing sites Manufacturing combination for biotechnology and synthetic technology Continual expansion and improvement for more effective production Ready to accommodate for better capacities reflecting customer demands Takasago Plant (Japan) Kaneka Singapore Biotechnology Synthetic Technology Facility Size Pilot ○ ○ Semi-commercial ○ ○ Commercial ○ ○ Plants for API’s ○ ○ Single Reactor Volume up to 100,000’s liters up to 10,000 liters * Glass-lined reactors * Stainless steel reactors Features * Immobilized microbe/enzyme * Segregation of recombinant microbes pursuant to regulation for manufacturing technology of recombinant DNA. * Effective connection with biotechnology plants

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